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In 1843, the pill world's "Nu Wa Niang" - the British Brockden created it in their own workshop, the creation of a very complex purpose: not to take the powder into tablets, often will stick in the mouth, too TM - - bitter! In advance, he used a ring and a pestle to press the medicine into round pieces。 A curious schoolmate might ask why it is round, why not a diamond, not a square。 I would like to ask you: if it's a square, don't you feel your voice? This method was carried out once it was spread。 Later, the tablets were made by pressing the copper mold。 At present, the tablets were made by hand pressing。 When pressing the tablets, a certain amount of drugs and excipients were mixed and evenly put into the mold。 The tablets were pressed into tablets by hammering up and down。 But the tablets made by this method are crushed with a click, and the dosage is not accurate, some tablets starch more main medicine, some tablets are simply the main medicine without starch, often take the first tablet, take the second tablet when life is GAME OVER, safety is too poor, "take medicine risks, medication needs to be careful" "Heavy" is not alarmist in advance。 It was not until the advent of tablet press in the 1970s that the consumption efficiency and quality of tablets were not guaranteed effectively, and this formulation was further promoted。
With the development of medicine, all kinds of treatments are changing with each passing day. Thinking about the advantages of slow acting and infinite acting parts, in order not to be eliminated by the times, tablets are unwilling to lag behind, and the frequent marriage of various advanced science and technology, gradually expanding the power of my family, so the tablet family has had more than a dozen tablets until tomorrow. Members, they are identified as oral tablets, buccal tablets, sublingual tablets, oral patches, chewing tablets, dispersible tablets... And so on, these members have their own disadvantages. Buccal tablets, which can dissolve gradually in the mouth and produce partial or systemic effects, followed by oral parts, play an anti-inflammatory, bactericidal, part of the anesthesia role, such as grass coral buccal tablets; and some emergency patients, such as angina pectoris, such as myocardial infarction, this disease is often sudden, even if the ordinary oral preparation timely Under the clothing, and through gastrointestinal metabolism ability to work, then the day lily is cold. Hence, there is an urgent need for a formulation that can take immediate effect without having to undergo various metabolic presentations, namely, sublingual tablets, which are indirectly absorbed by the capillaries of the sublingual mucosa to promote systemic action without passing through the liver and intestines. The most famous of these are sublingual nitroglycerin tablets, known as life-saving drugs; and some drugs. Things need to be released quickly, and some drugs need to be released at a constant rate. This is called controlled-release tablets. For example, in a complicated case, everyone has been in a car and knows that the car is moving fast or slow, and people are prone to carsickness. In a different way, when some drugs are swallowed into the body, the release is too fast or too slow, and the body can't stand it, so in order to get there The release rate of drugs fluctuated, and controlled release tablets were created. Controlled-release tablets are relatively high drug release requirements of the preparation, so more common in blood control agents, it is in a unit time with a relatively constant release dose to maintain a constant blood concentration, more durable efficacy, such as nifedipine controlled-release tablets. After talking about these famous tablets, we'll talk about the more interesting enteric-coated tablets, some of which are self-placebo to the stomach (such as aspirin) or effective after dissolving in the stomach, so people want the tablets not to be destroyed in the stomach, but to be absorbed in the small intestine, so the enteric-coated tablets came into being. Aspirin Enteric-coated Tablets is well known.
Having said so many members of the family of tablets, who will judge the good or bad of these members? This is the drug code, which, like our human laws, binds the actions of these members and weighs their merits. Among them, the characteristic norms are component differences, disintegration time limits and dispersion averages. It makes sense to compromise with the disease when the pill enters the body, just as it is difficult for a nation to conscript officially. As long as it is physically fit and capable, being too fat (too much medicine) or too thin (too little medicine) will be brushed away. Therefore, we should take tablets with statistical significance and calculate the difference of their components, which is the component difference, as long as the component difference is within the scope of the qualified source of arms. This goal is ineffective to avoid the extreme condition of "fat, thin, thin and dead" in tablets. Early years, tablets were not very good pressure, a little touch on the broken, with the improvement of science and technology, the hardness is up, but too solid as stone eggs can not ah, you know tablets eat to the outside of the stomach, is to collapse to explain the ability to play a role, if you eat what kind, discharge or what kind, then take medicine What else is there? So we set up a disintegration time limit test in the laboratory, which rules that it disintegrates in an instrument that mimics the human environment within a certain time. So long as such tablets are ineffective tablets, the "iron-core" diehards are removed from the tablet family. Dispersion evenness is the second most important objective of investigating the quality of dispersible tablets. When dispersed in water, the dispersible tablets can not have large particles beyond their size. The important objective of dispersible tablets is to disintegrate and dissolve quickly. If there are still large particles, what is the difference between dispersible tablets and ordinary tablets? How much does it cost for patients to spend more than a few times to buy dispersible tablets? You must be mean, and you must be mean when making tablets.
With the rapid development of pharmacokinetics and Informatics,